In a systematic review and meta-analysis we summarize the available evidence on how frequently general practitioners/family physicians (GPs) use pure placebos (e.g., placebo pills) and non-specific therapies (sometimes referred to as impure ...

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“I want you out there every day selling Neurontin. … We all know Neurontin's not growing for adjunctive therapy [when it gets combined with another medication], besides that's not where the money is. Pain management, now that's money…That's where we need to be, holding their hand and whispering in their ear, Neurontin for pain, Neurontin [alone], Neurontin for bipolar, Neurontin for everything. I don't want to see a single patient coming off Neurontin before they've been up to at least 4800 mg/day. I don't want to hear that safety crap either, have you tried Neurontin, every one of you should take one just to see there is nothing, it's a great drug.”

Among the findings of interest are the fact that the FDA rejected the application for gabapentin for diabetic peripheral neuropathy based on the risk versus benefit profile of that drug in the clinical trials that were submitted by the manufacturer. Additionally, both the comparative effectiveness trials as well as the studies used by the FDA tend to be short in duration and show only modest pain benefits for the gabapentinoids. The placebo response in these trials was frequently one-third to one-half as great as the pain benefit demonstrated by the gabapentinoid.

combination of guanfacine and N-acetylcysteine (NAC), an anti-oxidant also used for the treatment of TBI. The combined therapy, they found, was successful in relieving brain fog for their small cohort of patients.

Inside the real Eli Lilly, the fake sparked a panic, according to two people familiar with the matter who spoke on the condition of anonymity because they weren’t authorized to speak publicly. Company officials scrambled to contact Twitter representatives and demanded they kill the viral spoof, worried it could undermine their brand’s reputation or push false claims about people’s medicine. Twitter, its staffing cut in half, didn’t react for hours.

"That is a good idea, and it will have absolutely no effect unless three major agencies take action immediately," says Kertesz. "The DEA, the National Committee for Quality Assurance, and the Centers for Medicare and Medicaid Services, all three agencies use the dose thresholds from the 2016 guideline as the basis for payment quality metrics and legal investigation."

The ability to coordinate and fix the harms that came from the 2016 guidance relies on leadership from the CDC"

...so we're fucked.

A medication prescribed for Parkinson’s and other diseases can transform a patient’s personality, unleashing heroic bouts of creativity or a torrent of shocking, even criminal behavior